The study proposes to examine the evolution and impact of E-newspapers on the Ugandan press using a mixed methods case study design on two newspapers, New Vision and Daily Monitor during 2011–2021. Globally, the newspaper industry is struggling to survive amidst falling circulations and the effects of the COVID-19 pandemic. The newspaper industry is struggling amidst falling circulations, aftereffects of the COVID-19 pandemic, and mushrooming [alternative] online news sources. Some scholars predict the complete demise of newspapers due to threats posed by online social media and news aggregators like Google. In response to technological and political economic threats, several newspapers have adopted electronic publication and circulation hoping to “catch up” with, and survive amidst these postmodern alternatives. In Africa generally, and Uganda in particular, a number of newspapers have adopted electronic publication and circulation models hoping to improve their readerships and revenue generation streams. What still eludes scholarship, however, is an understanding of the impact the adoption of digital technologies, in the form of E-newspapers, has had on the newspaper industry. The extant scholarship, however, lacks an appropriate framework for examining the evolution and impact of digitalisation, specifically E-newspapers, for the newspaper industry. The study combines theoretical and conceptual resources from the Critical Political Economy and the Social Shaping of Technology theories to develop the framework for the examination of the evolution and impact of E-newspapers on the press in Uganda and beyond.  The study adopts a mixed methods case study design and findings will fill current gaps in the study of E-newspapers in Uganda and beyond, and propose areas for further research and action.